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From Crisis to Consensus: Guidelines Aim to Reduce Over-Prescribing of Abused Drugs

From Crisis to Consensus: Guidelines Aim to Reduce Over-Prescribing of Abused Drugs

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Every day, 115 Americans are killed by opioid overdose. That this number is so strikingly high underlines the language of ‘“epidemics” and “emergencies” in politicians’ speeches and newspaper headlines. Thousands of articles and millions of research dollars have become components of a concerted effort to understand, quantify and alleviate the opioid epidemic in the United(...)

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The Colorful World of Cancer Drug Discovery

The Colorful World of Cancer Drug Discovery

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Melanoma cells stained with PTRF (in red), RPA194 (in green) and nucleus stained in blue. RPA194 is the main subunit of the RNA polymerase I (POL 1) enzyme. Our lab discovered a first-in-class small molecule that inhibits POL 1 enzyme and causes the destruction of RPA194 protein. Here, we are investigating how these proteins are(...)

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Do You Want to Write for Us?

Do You Want to Write for Us?

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Our medical students, residents, postdocs and fellows have a lot to share — from daily life in the classroom, tips on surviving residency, new research that is pushing the boundaries of science and patient care, to the best places to grab a bite in Baltimore, they share it here. If you have a love of(...)

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Landmark RNAi-Based Therapy Achieves Clinical Success

Landmark RNAi-Based Therapy Achieves Clinical Success

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DNA serves as a blueprint for the protein repertoire that comprises the human body and its functions. To construct these proteins while also ensuring that its DNA remains safely tucked away in the nucleus, the cell generates disposable and short-lived copies of its active genes, called messenger RNA (mRNA). An array of molecular machines then(...)

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Targeting Diabetes with a High-Fiber Diet: It’s All in Your Gut!

Targeting Diabetes with a High-Fiber Diet: It’s All in Your Gut!

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Right this moment, your gastrointestinal tract is crammed with a vast number of different microbes, together referred to as the human gut microbiota. Don’t be too alarmed though, as this complex gut microbial ecosystem maintains a mutual and beneficial relationship with you. Given the bad reputation some bacteria have as being infectious and antibiotic-resistant, you(...)

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Insilico Medicine: A Hopkins Startup Using AI to Enhance Biomedical Research

Insilico Medicine: A Hopkins Startup Using AI to Enhance Biomedical Research

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Remember that time you Googled something and it showed up on your Facebook newsfeed the next day? These oftentimes unnerving, targeted advertising strategies are driven by gradations of artificial intelligence (AI) and machine learning software, which constantly improve and build in sophistication. The power in these programs lies in their ability to find patterns between(...)

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Who Let the Dogs Out?

Who Let the Dogs Out?

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I occasionally find myself walking through the dark underbelly of the Johns Hopkins medical campus along “designated laboratory transport” routes. These concrete tunnels allow researchers to transport equipment or mice from animal facilities to laboratories without passing through patient areas. I always feel a pang of sadness when I see stacks of dog food in(...)

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To Infinity and Beyond

To Infinity and Beyond

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On Tuesday, Feb. 6, SpaceX launched the Falcon Heavy rocket, sending one of Elon Musk’s Teslas into space. The rocket has an awesome amount of power, with nine main rocket engines and 27 total engines used to send the vehicle into space. This is the most engines a rocket has ever used! In fact, Musk(...)

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