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Partnering Toward Discovery: A Focus on Inclusion Body Myositis

Partnering Toward Discovery: A Focus on Inclusion Body Myositis

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Many people are not familiar with a rare disease called inclusion body myositis (IBM). Most have never heard of it. On Jan. 22, 2019, Harry Benjamin Larman and students Janelle Montagne, Sahana Jayaraman and Kyla Britson presented their clinical and basic science research on IBM at the first event in this year’s Partnering Toward Discovery(...)

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Engineering Magic Bullets for Pancreatic Cancer

Engineering Magic Bullets for Pancreatic Cancer

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In a 1909 manuscript titled “Ueber den jetzigen Stand der Chemotherapie” (“About the Current State of Chemotherapy”), Nobel laureate Paul Ehrlich proclaimed, “We must learn to aim in a chemical sense.” What did he mean? Ehrlich was referring to his “magic bullet” theory of chemical specificity, the observation that certain drugs can eliminate disease-causing entities(...)

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The Relationship Between Age and Blood Pressure: Another Way Your Lifestyle Can Impact Heart Health

The Relationship Between Age and Blood Pressure: Another Way Your Lifestyle Can Impact Heart Health

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Many of us have likely experienced recent high blood pressure. Whether it’s from well-meaning but very inquisitive relatives, or the winding lines at the airport, most of us are acquainted with a temporary rise in blood pressure under stress. And unfortunately, high blood pressure (BP) is a common chronic issue for millions of people worldwide.(...)

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Thinking Outside the Brain

Thinking Outside the Brain

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Genetics began in the garden — Mendel’s pea experiments revolutionized and developed the field and principles we know and study today. Similarly, my scientific journey began with plants. In college, I studied the model organism Chlamydomonas reinhardtii, which is unique in its ability to thrive in total darkness, whereas most plants rely on photosynthesis. My(...)

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The Link Between Metabolism and Anti-Tumor Immunity: Implications for Glioma Therapy

The Link Between Metabolism and Anti-Tumor Immunity: Implications for Glioma Therapy

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As a callow biochemistry student, I often grappled with the onerous task of memorizing metabolic pathways. Gradually, however, I came to appreciate the underlying simplicity: Complex macromolecules are broken down to the same simple molecule. Metabolism is the workhorse of the cell — efficiently mining nutrients for energy, shunting surplus nutrients to build cellular structures,(...)

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Understanding the Epidemics of Today to Prevent Those of Tomorrow

Understanding the Epidemics of Today to Prevent Those of Tomorrow

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Though it may seem distant now, 2014 was a tumultuous year for the global health community. One of the worst Ebola epidemics in history was ravishing communities in West Africa, spreading to health care workers, sparking superstitions among locals and demonstrating how devastating a single virus can be on the world stage. Many likely remember(...)

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