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Out with the Old, in with Repaired Joints

Out with the Old, in with Repaired Joints

Posted by  | Perspectives in Research, Recently Published

Osteoarthritis (OA) is not only the most common chronic condition of the joints, but also the most common type of arthritis, affecting approximately 27 million Americans.1 The prevalence of OA increases with age,2 and elderly patients experience swelling, pain and decreased mobility. Currently, there is no cure for this degenerative joint disease, and the only(...)

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A Revelation About DREADDs: A New Neuroscience Technique with Promise for Clinical Psychiatric Treatment

A Revelation About DREADDs: A New Neuroscience Technique with Promise for Clinical Psychiatric Treatment

Posted by  | Perspectives in Research, Recently Published

In an essay I published last year for the Lasker Essay Contest (and republished in our blog), I described optogenetics and chemogenetics, two technologies recently developed for basic neuroscience research that have the potential to improve the way we treat psychiatric illness. The major drawback to drugs currently prescribed for diseases such as depression, PTSD,(...)

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Smarter Antimalarial Use: Altering Drug Duration to Improve Efficacy

Posted by  | Perspectives in Research, Recently Published

Fighting malaria is getting harder, with rising rates of drug resistance and drug tolerance making it more difficult for doctors to effectively cure patients. Drug resistance is distinct from drug tolerance, in that a resistant microbe can survive even high doses of a particular drug, while tolerant microbes are able to replicate in the drug’s(...)

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Ecstasy and Agony: Accepting MDMA-Assisted Psychotherapy as a Breakthrough PTSD Treatment

Posted by  | Perspectives in Research, Recently Published

For the majority of the population, MDMA, or ecstasy, is simply an illegal drug, its use exclusive to underground dance clubs and its abuse the purview of the police. However, a small group of psychopharmacological researchers and advocates have been touting this compound as the next major frontline treatment for a variety of troubling psychological(...)

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Understanding Disparities in Clinical Trial Enrollment

Understanding Disparities in Clinical Trial Enrollment

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When scientists and clinicians hear the words “clinical trial”, we may think of hope, discovery, and a new chance at life. But for racial and ethnic minorities, these words may not have the same positive connotation but may rather be associated with inaccessibility, fear, and exclusion. The potential benefits for patients who participate in clinical(...)

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Does My Sense of Smell Make Me Look Fat?

Does My Sense of Smell Make Me Look Fat?

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Long before we see or taste food, what strikes us most is its aroma wafting through the air. While eating, what we perceive as taste is not only due to the sensation on our taste buds, but is also mediated by our sense of smell. Although we can detect only five primary tastes, we are(...)

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First Approval of Cancer Immunotherapy Based on Genetic Marker

First Approval of Cancer Immunotherapy Based on Genetic Marker

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Immunotherapy is rapidly becoming one of the cornerstones of treatment for several types of cancers, and pembrolizumab, a well-known humanized antibody against the checkpoint inhibitor programmed death 1 (PD-1), is again in the spotlight for new expanded use based on patient's genetic differences. In a first of its kind, the U.S. Food and Drug Administration(...)

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Human Cord Blood Improves Memory in Old Mice – Surge of Interest in the “Fountain of Youth”

Human Cord Blood Improves Memory in Old Mice – Surge of Interest in the “Fountain of Youth”

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Is parabiosis the new fountain of youth? Parabiosis, meaning “living beside,” is a 150-year-old surgical technique that unites the blood vessels of two living animals. One of the earliest accounts of parabiosis comes from the mid-1800s when a French zoologist, Paul Bert, attached the circulatory systems of two animals and demonstrated that fluid injected into(...)

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