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The Link Between Metabolism and Anti-Tumor Immunity: Implications for Glioma Therapy

The Link Between Metabolism and Anti-Tumor Immunity: Implications for Glioma Therapy

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As a callow biochemistry student, I often grappled with the onerous task of memorizing metabolic pathways. Gradually, however, I came to appreciate the underlying simplicity: Complex macromolecules are broken down to the same simple molecule. Metabolism is the workhorse of the cell — efficiently mining nutrients for energy, shunting surplus nutrients to build cellular structures,(...)

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Understanding the Epidemics of Today to Prevent Those of Tomorrow

Understanding the Epidemics of Today to Prevent Those of Tomorrow

Posted by  | Perspectives in Research, Recently Published

Though it may seem distant now, 2014 was a tumultuous year for the global health community. One of the worst Ebola epidemics in history was ravishing communities in West Africa, spreading to health care workers, sparking superstitions among locals and demonstrating how devastating a single virus can be on the world stage. Many likely remember(...)

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A New Animal Model for Bad Decisions

A New Animal Model for Bad Decisions

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Humans are constantly making decisions about how to spend time, yet we are pretty terrible at doing so effectively. We sit through boring movies, stay in line at a crowded restaurant and continue to pursue low-return projects, because we simply cannot bear to see the time we have already invested in these activities go to(...)

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Diversity at the Top of the Social Media Signaling Cascade

Diversity at the Top of the Social Media Signaling Cascade

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Caroline's essay received 3rd place in The Lasker Foundation Essay Contest. The Lasker Foundation’s Essay Contest engages young scientists and clinicians in a discussion about big questions in biology and medicine and the role of biomedical research in our society today.  The Contest aims to build skills in communicating important medical and scientific issues to(...)

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Finding the Missing Piece — the Limits of the Current Malaria Vaccine and How We Can Improve Future Vaccine Design

Finding the Missing Piece — the Limits of the Current Malaria Vaccine and How We Can Improve Future Vaccine Design

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With hundreds of millions of infections worldwide, malaria continues to be a global health threat and burden to vulnerable populations. For decades, researchers have dedicated work to stamping out this illness, which is caused by the parasite Plasmodium falciparum, and a vaccine was recently licensed for prevention of the disease. The vaccine, called RTS,S/AS01, has(...)

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Advice for Fellowship Applications – Part One

Advice for Fellowship Applications – Part One

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For graduate students, the first years of the Ph.D. are packed with an array of hurdles, and it is easy to end up feeling overwhelmed. Once you have passed your qualifying exams, chosen a thesis laboratory, finished the majority of your coursework and have a good general direction for your thesis project — roughly mid-second(...)

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A Novel Cancer Immunotherapy Unveiled: Y-Traps

A Novel Cancer Immunotherapy Unveiled: Y-Traps

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The human immune system is composed of a diverse array of cells, which collectively work to exterminate pathogenic entities in the body. Yet this system is able to recognize host, or self, tissues as “friendly” through a variety of so-called immune checkpoint signals. Many cancer types — including melanomas and breast cancers — exploit this(...)

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