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A Promising Therapeutic Target for Heart Failure

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Approximately 50 percent of patients with heart failure die within five years of diagnosis due to lack of an effective cure. Scientists are working to improve this statistic. Heart failure can be caused by several of the most common medical conditions, such as coronary artery disease, high blood pressure and diabetes, which can compromise the(...)

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Snapshot of a DNA Photocopier in ‘Hibernate’ Mode Reveals Potential Origin for Dwarfism

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When attempting to elucidate the function of biological macromolecules, visual representations can be extremely useful tools. Often, these tools can help pinpoint the structural origin of a particular function and are invaluable for understanding how complex systems work. Sometimes it’s just easier to grasp something when you can see it. That said, obtaining these structures(...)

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Johns Hopkins Scientists Discover a Novel Mechanism for β-Lactam Antibiotic Synthesis

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Some oft-prescribed antibiotics, including penicillin and cephalosporin, share a common motif in their chemical structure: a small group of atoms arranged in a ring, called a β-lactam. These β-lactam antibiotics utilize this unusual structure to disrupt the cell wall synthesis in bacteria, greatly inhibiting their ability to spread throughout the body. Unfortunately, how these ring(...)

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