Recently Published

Managing Burnout: Advice for New Medical Trainees

Posted by  | Recently Published

The white coats these days are at their starchiest, the haircuts are fresh and even the Tylenol orders are being triple-checked — it’s July again at The Johns Hopkins Hospital. That is to say, the academic medicine new year has come and gone, and a flock of some 26,000 wide-eyed but eager new physicians have(...)

More

Multiple Mechanisms Underlie Human Motor Learning

Posted by  | Recently Published

How do musicians know how to move their arms and fingers — and in some cases, feet — to create beautiful chords and harmonics? How are athletes able to acquire skills that make them so awe-inspiring? How do humans generally learn a motor skill and learn how to control all of our limbs in a(...)

More

A Promising Therapeutic Target for Heart Failure

Posted by  | Recently Published

Approximately 50 percent of patients with heart failure die within five years of diagnosis due to lack of an effective cure. Scientists are working to improve this statistic. Heart failure can be caused by several of the most common medical conditions, such as coronary artery disease, high blood pressure and diabetes, which can compromise the(...)

More

Snapshot of a DNA Photocopier in ‘Hibernate’ Mode Reveals Potential Origin for Dwarfism

Posted by  | Recently Published

When attempting to elucidate the function of biological macromolecules, visual representations can be extremely useful tools. Often, these tools can help pinpoint the structural origin of a particular function and are invaluable for understanding how complex systems work. Sometimes it’s just easier to grasp something when you can see it. That said, obtaining these structures(...)

More

Johns Hopkins Scientists Discover a Novel Mechanism for β-Lactam Antibiotic Synthesis

Posted by  | Recently Published

Some oft-prescribed antibiotics, including penicillin and cephalosporin, share a common motif in their chemical structure: a small group of atoms arranged in a ring, called a β-lactam. These β-lactam antibiotics utilize this unusual structure to disrupt the cell wall synthesis in bacteria, greatly inhibiting their ability to spread throughout the body. Unfortunately, how these ring(...)

More