Liang Han is undergoing a transition.

As a postdoctoral researcher in the lab of Xinzhong Dong, she is preparing for a major career move to become an independent investigator. That transition is aided by the fact that Han is the recipient of a National Institute of Health (NIH) Pathway to Independence Award, known to many by its grant identifier, K99.

Liang HanThe K99 is a prestigious award given by NIH to postdoctoral fellows and provides funding to facilitate their move to independent investigator. Along with providing funds for their research, having a K99 award makes them a more competitive applicant for academic research positions. Han’s funded award is titled “Molecular and Cellular Mechanisms of Itch Sensation” and continues the line of work she undertook in Dong’s lab, while also setting out to study new aspects of the itch sensation.

Han’s research concerns receptors found on sensory neurons called Mas-related G protein–coupled receptors (Mrgprs). Along with her colleagues in the Dong lab, Han has published research articles in many high-impact journals implicating these receptors in contributing to pruritogen-induced itch. Han’s published work in Nature Neuroscience was the first to demonstrate the molecular identity of itch-sensing neurons innervating the skin1.

When I asked her why she studied itch, her matter-of-fact answer was: “Because I am a victim of chronic itch. My skin is supersensitive and is always itchy. When it is possible, I always prefer to work on something that is related to my own everyday life.”

Her impressive work and early success in publishing helped make her a competitive applicant for the K99, being all the more remarkable because this is Han’s first grant. I asked if she had any advice for postdocs applying for this award. “Start early — from the first year during a postdoc — talk to other awardees and keep trying. Having your own grant means a lot for postdoc researchers, especially for those who are pursuing careers in academia. It allows you to work on the topic you are excited about and provides more opportunities for career development.”

Han is ending the initial phase of mentored grant support and will be moving onward with the fully independent portion at the Georgia Institute of Technology. She now finds herself busy completing projects here while preparing the groundwork for her new faculty position.

Is she nervous about starting a new job? “I’m actually excited,” she explains with a smile.

  1. Han, L., et al., A subpopulation of nociceptors specifically linked to itch. Nat Neurosci, 2013. 16(2): p. 174-82.


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