Melanoma cells stained with PTRF (in red), RPA194 (in green) and nucleus stained in blue. RPA194 is the main subunit of the RNA polymerase I (POL 1) enzyme. Our lab discovered a first-in-class small molecule that inhibits POL 1 enzyme and causes the destruction of RPA194 protein. Here, we are investigating how these proteins are regulated by the new molecule in the cancer cells. This may allow us to understand the value of targeting RNA POL 1 in cancer, and support its development as a novel therapeutic strategy for cancer patients.
Jin-Yih’s work is featured on our new JHM.Fundamentals Instagram account, which showcases basic science images from students and faculty members at Johns Hopkins. Do you have cool images to share? Submit them here!