Perspectives in Research

Uncovering How a Diabetes Drug Slows Cancer Growth

Uncovering How a Diabetes Drug Slows Cancer Growth

Posted by  | Perspectives in Research

What do a relatively unknown gene, a well-known signaling pathway and nuclear transport have in common? They’re all part of how diabetes and cancer drug metformin works. Metformin is a widely used type 2 diabetes drug that lowers glucose levels and sensitizes cells to insulin. Metformin’s mechanism has been long sought after, and studies into(...)

More

Breaking Down Where the Money Goes: Personal and Public Health Care Spending in the United States

Breaking Down Where the Money Goes: Personal and Public Health Care Spending in the United States

Posted by  | Perspectives in Research, Recently Published

The United States spends more money on health care than any other country — $2.9 trillion in 2014, or about $9,110 per person. Spending continues to increase. With the arrival of the new Trump administration, the debate on health care costs is heightening. In preparation, let’s take a closer look at U.S. health care costs(...)

More

New Frontiers in Major Depressive Disorder Treatment

New Frontiers in Major Depressive Disorder Treatment

Posted by  | Perspectives in Research

Major depressive disorder (MDD) afflicts more than 250 million people worldwide and is the most common source of disability for Americans. In addition to counseling and talk therapy, there is a veritable alphabet soup of medications, from amitriptyline to venlafaxine, currently prescribed to treat MDD. Each class of antidepressant acts on an individual or combination(...)

More

Controversy Over Male Contraceptive Study

Controversy Over Male Contraceptive Study

Posted by  | Perspectives in Research, Recently Published

Today, adult women have a wide variety of choices of birth control methods, including daily pills, implants, IUDs and others. However, there is still no equivalent method of birth control for men, who have historically been limited to withdrawal, condoms and sterilization, placing the burden of pregnancy prevention on females. A recent study, co-sponsored by(...)

More

Who Has Time to Sleep?

Who Has Time to Sleep?

Posted by  | A Day in the Life, Perspectives in Research

At the proverbial watercooler in teaching hospitals across the world, one hears remarkably similar refrains: “This patient is back again,” “I have no idea why my experiment failed this time” and, most universally, “I’ve only slept three hours in the past two days!” Medical trainees often view sleep deprivation as a badge of honor, one(...)

More

Gene Editing Under Fire

Gene Editing Under Fire

Posted by  | Perspectives in Research

CRISPR/Cas9 gene editing is the hottest new technology being used by molecular biologists and geneticists around the world. The method, first developed in prokaryotes in a collaboration between Jennifer Doudna’s group at University of California, Berkeley and Emmanuelle Charpentier’s lab at the Pasteur Institute in June 2012, allows targeted editing of the genomes of living(...)

More

At the Vanguard of the Psychedelic Renaissance

At the Vanguard of the Psychedelic Renaissance

Posted by  | Did You See This?, Perspectives in Research

A priest, a minister and a rabbi walk into Johns Hopkins Bayview Medical Center to ingest psilocybin, the active ingredient in hallucinogenic mushrooms. Although this probably sounds like the beginning of a great joke, new advancements in the field of psychedelic medicine are no laughing matter. After nearly 50 years of prohibition, academic studies and clinical(...)

More

Nobel Prize Winning Research May Lead to New Therapies for Cancer, Alzheimer’s

Nobel Prize Winning Research May Lead to New Therapies for Cancer, Alzheimer’s

Posted by  | Did You See This?, Perspectives in Research

Yoshinori Ohsumi of the University of Tokyo was recently awarded the 2016 Nobel Prize in Physiology or Medicine for his work in mechanisms for autophagy. What is autophagy? From the Greek roots “auto,“ or self, and “phagia,” or eating, the word literally means self-eating. In cell biology, autophagy describes the way that cells recycle unneeded(...)

More

Cancer Drug Shows Surprising Potential as Parkinson’s Treatment

Cancer Drug Shows Surprising Potential as Parkinson’s Treatment

Posted by  | Perspectives in Research, Recently Published

Parkinson’s disease is a neurodegenerative condition caused by the death of dopamine-producing cells in a region of the brain called the substantia nigra, which leads to disruptions in neural circuits controlling motor function. Although the cause of this inappropriate cell death is largely unclear, one hypothesis is that it is due to the abnormal aggregation(...)

More