The development and commercialization of cancer immunotherapies, a class of treatments that fights cancer by fortifying the immune system, has advanced at a rapid pace. Prior to 2017, most cancer immunotherapies were composed of antibodies that selectively flag cancer cells for destruction by other cells in the immune system. In mid-2017, the FDA approved Kymriah(...)
Perspectives in Research
The Puppets of Parasites
Posted by | Perspectives in ResearchWe’ve all experienced illnesses where parasites or small infectious agents such as bacteria and viruses are the culprits. But what happens when those pathogens start to influence the behavior of their hosts? Here I’ll discuss three different parasites that manipulate host behavior, delineate some potential mechanisms for their influence and outline some of the theory(...)
The Colorful World of Cancer Drug Discovery
Posted by | Perspectives in ResearchMelanoma cells stained with PTRF (in red), RPA194 (in green) and nucleus stained in blue. RPA194 is the main subunit of the RNA polymerase I (POL 1) enzyme. Our lab discovered a first-in-class small molecule that inhibits POL 1 enzyme and causes the destruction of RPA194 protein. Here, we are investigating how these proteins are(...)
The Link Between Metabolism and Anti-Tumor Immunity: Implications for Glioma Therapy
Posted by | Perspectives in ResearchAs a callow biochemistry student, I often grappled with the onerous task of memorizing metabolic pathways. Gradually, however, I came to appreciate the underlying simplicity: Complex macromolecules are broken down to the same simple molecule. Metabolism is the workhorse of the cell — efficiently mining nutrients for energy, shunting surplus nutrients to build cellular structures,(...)
Understanding the Epidemics of Today to Prevent Those of Tomorrow
Posted by | Perspectives in ResearchThough it may seem distant now, 2014 was a tumultuous year for the global health community. One of the worst Ebola epidemics in history was ravishing communities in West Africa, spreading to health care workers, sparking superstitions among locals and demonstrating how devastating a single virus can be on the world stage. Many likely remember(...)
A New Animal Model for Bad Decisions
Posted by | Perspectives in ResearchHumans are constantly making decisions about how to spend time, yet we are pretty terrible at doing so effectively. We sit through boring movies, stay in line at a crowded restaurant and continue to pursue low-return projects, because we simply cannot bear to see the time we have already invested in these activities go to(...)
Open Access: Making Scientific Findings Available to All
Posted by | A Day in the Life, Perspectives in ResearchMost would agree that a principal goal of scientific research is to enhance society’s understanding of the world around us. In biomedical research, we are particularly interested in discovering the workings of the body to find better treatments for disease and enact better guidelines and policies for healthy living. A crucial element of this endeavor(...)
Do You Want to Write for Us?
Posted by | Perspectives in ResearchOur medical students, residents, postdocs and fellows have a lot to share — from daily life in the classroom, tips on surviving residency, new research that is pushing the boundaries of science and patient care, to the best places to grab a bite in Baltimore, they share it here. If you have a love of(...)
The Science of Snoring
Posted by | Perspectives in ResearchThere are few disciplines in science and medicine as broadly important, or as inherently relatable, as the study of sleep. During the annual Johns Hopkins Sleep and Circadian Research Day, a disparate group of clinicians, epidemiologists, geneticists and basic researchers gather to share posters and present new findings at the vanguard of sleep research on(...)
Using Our Inside Voices as Scientists
Posted by | Perspectives in ResearchIt’s hard to change people’s minds. Controversial topics such as climate change and vaccines are not exempt from our inherent obstinateness. Scientists assume the solution to persuasion is more effective communication. A wealth of podcasts, Twitter accounts and YouTube channels are dedicated to the digestion and dissemination of scientific information. Even Bill Nye attempts to “save(...)