Challenges are inevitable, particularly for those working in STEM fields. Ph.D. candidate Roshan Chikarmane shares a story that demonstrates how to recognize strategic inflection points and emerge more resilient than before.
Roshan Chikarmane
About Roshan Chikarmane
Posts by Roshan Chikarmane:
Businesses Innovation: A Cure for the Drug Pricing Dilemma
Ph.D. candidate Roshan Chikarmane identifies key drivers of rising drug prices and introduces corresponding interventions that are being undertaken by business leaders to shift industry trends toward more affordable health care.
Genome Engineering Emerges from the Shadows
The fruits of modern molecular biology offer us a powerful tool that allows us to engineer the genetic code of virtually any organism. Early therapeutic applications could foreshadow an inflection point for the positioning of genome engineering in modern health care.
The Biopharma Startup: A Heart-Pounding Venture
Here’s how a group of passionate thinkers turned scholarly insights into therapies that could help millions of patients with heart failure.
Cancer Diagnosis — It’s in Your Blood
The benefits of detecting and treating cancer at early developmental stages have long been observed by clinical oncologists. Colonoscopies as well as other methods for early detection have been estimated to prevent as many as 60% of deaths attributable to colorectal cancer by identifying and removing precancerous growths1. More broadly, patients with early stage cancer […]
Engineering Magic Bullets for Pancreatic Cancer
In a 1909 manuscript titled “Ueber den jetzigen Stand der Chemotherapie” (“About the Current State of Chemotherapy”), Nobel laureate Paul Ehrlich proclaimed, “We must learn to aim in a chemical sense.” What did he mean? Ehrlich was referring to his “magic bullet” theory of chemical specificity, the observation that certain drugs can eliminate disease-causing entities […]
The Life and Times of a Principled Scientist
In a world that amounts to a maelstrom of stimuli and a cacophony of interacting processes, it is of great importance that one develops systems for recognizing specific types of scenarios and reacting appropriately to them. These systems, or principles, inform our future decision-making and spare us the tedium of having to deal with all […]
Solving the CAR-T Conundrum
The development and commercialization of cancer immunotherapies, a class of treatments that fights cancer by fortifying the immune system, has advanced at a rapid pace. Prior to 2017, most cancer immunotherapies were composed of antibodies that selectively flag cancer cells for destruction by other cells in the immune system. In mid-2017, the FDA approved Kymriah […]
Landmark RNAi-Based Therapy Achieves Clinical Success
DNA serves as a blueprint for the protein repertoire that comprises the human body and its functions. To construct these proteins while also ensuring that its DNA remains safely tucked away in the nucleus, the cell generates disposable and short-lived copies of its active genes, called messenger RNA (mRNA). An array of molecular machines then […]
Three-Minute Thesis: A Case Study in the Economics of Communication
Photo courtesy of hub.jhu.edu Economics is defined, in practice, as the act of efficiently allocating scarce resources so as to best suit the wants and needs of humankind. In the context of a factory, this notion could refer to the efficient allocation of input commodities, such as steel and plastic, so as to maximize the production […]
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