Roshan Chikarmane

About Roshan Chikarmane

Roshan Chikarmane is a passionate cancer researcher who also has interests in running, finance and reading. His role model is Sidney Farber, the “father of modern chemotherapy.”

Posts by Roshan Chikarmane:

The Life and Times of a Principled Scientist

The Life and Times of a Principled Scientist

In a world that amounts to a maelstrom of stimuli and a cacophony of interacting processes, it is of great importance that one develops systems for recognizing specific types of scenarios and reacting appropriately to them. These systems, or principles, inform our future decision-making and spare us the tedium of having to deal with all(...)

More

Solving the CAR-T Conundrum

Solving the CAR-T Conundrum

The development and commercialization of cancer immunotherapies, a class of treatments that fights cancer by fortifying the immune system, has advanced at a rapid pace. Prior to 2017, most cancer immunotherapies were composed of antibodies that selectively flag cancer cells for destruction by other cells in the immune system. In mid-2017, the FDA approved Kymriah(...)

More

Landmark RNAi-Based Therapy Achieves Clinical Success

Landmark RNAi-Based Therapy Achieves Clinical Success

DNA serves as a blueprint for the protein repertoire that comprises the human body and its functions. To construct these proteins while also ensuring that its DNA remains safely tucked away in the nucleus, the cell generates disposable and short-lived copies of its active genes, called messenger RNA (mRNA). An array of molecular machines then(...)

More

Three-Minute Thesis: A Case Study in the Economics of Communication

Three-Minute Thesis: A Case Study in the Economics of Communication

Photo courtesy of hub.jhu.edu Economics is defined, in practice, as the act of efficiently allocating scarce resources so as to best suit the wants and needs of humankind. In the context of a factory, this notion could refer to the efficient allocation of input commodities, such as steel and plastic, so as to maximize the production(...)

More

A Novel Cancer Immunotherapy Unveiled: Y-Traps

A Novel Cancer Immunotherapy Unveiled: Y-Traps

The human immune system is composed of a diverse array of cells, which collectively work to exterminate pathogenic entities in the body. Yet this system is able to recognize host, or self, tissues as “friendly” through a variety of so-called immune checkpoint signals. Many cancer types — including melanomas and breast cancers — exploit this(...)

More