In a 1909 manuscript titled “Ueber den jetzigen Stand der Chemotherapie” (“About the Current State of Chemotherapy”), Nobel laureate Paul Ehrlich proclaimed, “We must learn to aim in a chemical sense.” What did he mean? Ehrlich was referring to his “magic bullet” theory of chemical specificity, the observation that certain drugs can eliminate disease-causing entities(...)
About Roshan Chikarmane
Posts by Roshan Chikarmane:
The Life and Times of a Principled Scientist
In a world that amounts to a maelstrom of stimuli and a cacophony of interacting processes, it is of great importance that one develops systems for recognizing specific types of scenarios and reacting appropriately to them. These systems, or principles, inform our future decision-making and spare us the tedium of having to deal with all(...)
Solving the CAR-T Conundrum
The development and commercialization of cancer immunotherapies, a class of treatments that fights cancer by fortifying the immune system, has advanced at a rapid pace. Prior to 2017, most cancer immunotherapies were composed of antibodies that selectively flag cancer cells for destruction by other cells in the immune system. In mid-2017, the FDA approved Kymriah(...)
Landmark RNAi-Based Therapy Achieves Clinical Success
DNA serves as a blueprint for the protein repertoire that comprises the human body and its functions. To construct these proteins while also ensuring that its DNA remains safely tucked away in the nucleus, the cell generates disposable and short-lived copies of its active genes, called messenger RNA (mRNA). An array of molecular machines then(...)
Three-Minute Thesis: A Case Study in the Economics of Communication
Photo courtesy of hub.jhu.edu Economics is defined, in practice, as the act of efficiently allocating scarce resources so as to best suit the wants and needs of humankind. In the context of a factory, this notion could refer to the efficient allocation of input commodities, such as steel and plastic, so as to maximize the production(...)
A Novel Cancer Immunotherapy Unveiled: Y-Traps
The human immune system is composed of a diverse array of cells, which collectively work to exterminate pathogenic entities in the body. Yet this system is able to recognize host, or self, tissues as “friendly” through a variety of so-called immune checkpoint signals. Many cancer types — including melanomas and breast cancers — exploit this(...)