cancer treatment

Solving the CAR-T Conundrum

Solving the CAR-T Conundrum

Posted by  | Perspectives in Research

The development and commercialization of cancer immunotherapies, a class of treatments that fights cancer by fortifying the immune system, has advanced at a rapid pace. Prior to 2017, most cancer immunotherapies were composed of antibodies that selectively flag cancer cells for destruction by other cells in the immune system. In mid-2017, the FDA approved Kymriah(...)

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The Link Between Metabolism and Anti-Tumor Immunity: Implications for Glioma Therapy

The Link Between Metabolism and Anti-Tumor Immunity: Implications for Glioma Therapy

Posted by  | Recently Published

As a callow biochemistry student, I often grappled with the onerous task of memorizing metabolic pathways. Gradually, however, I came to appreciate the underlying simplicity: Complex macromolecules are broken down to the same simple molecule. Metabolism is the workhorse of the cell — efficiently mining nutrients for energy, shunting surplus nutrients to build cellular structures,(...)

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Using Epigenetics to Fight Tumors

Using Epigenetics to Fight Tumors

Posted by  | Perspectives in Research, Recently Published

While the word cancer treatment may identify everything from chemotherapy to radiation, there is significant variance between the type of cancer and its responsiveness to even the most promising therapies. That has been precisely the case for the α-PD-1 immunotherapy treatment. While it has shown remarkable efficacy in patients diagnosed with lung cancer, other types(...)

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Double Duty: Repurposing Drugs for Novel Cancer Treatment

Double Duty: Repurposing Drugs for Novel Cancer Treatment

Posted by  | Perspectives in Research

What do an anti-parasitic drug used to treat pinworms and a frequently used anti-malarial drug have in common? According to recent studies from the labs of Johns Hopkins and University of Kentucky investigators, both mebendazole and chloroquine could be promising medicines to combat cancer. Mebendazole has been in use as an anti-helminthic drug since 1971.(...)

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Cancer Drug Shows Surprising Potential as Parkinson’s Treatment

Cancer Drug Shows Surprising Potential as Parkinson’s Treatment

Posted by  | Perspectives in Research, Recently Published

Parkinson’s disease is a neurodegenerative condition caused by the death of dopamine-producing cells in a region of the brain called the substantia nigra, which leads to disruptions in neural circuits controlling motor function. Although the cause of this inappropriate cell death is largely unclear, one hypothesis is that it is due to the abnormal aggregation(...)

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