Biomedical Odyssey

Life at the Johns Hopkins School of Medicine

A cute elementary age girl with cancer is wearing a pink scarf on her head. She is at a medical appointment. The female doctor of African descent is holding the child's hands, providing comfort and support. The child is smiling at the camera.

Oncology: Offering Hope to Patients in Need

December 4, 2020

Much of the general public believes oncology is a “sad” field. Amol Narang, and many other practicing oncologists, disagree. Learn about his inspiring profession and why he would choose to be an oncologist time and time again.

Palak Patel ⋅ Events and Happenings Cancer, interview, Oncology, Patient Care, radiation oncology ⋅

Sunrise at Portland Lighthouse, New England, Maine

Foghorn Therapeutics Breaks New Ground in Cancer Epigenetics

December 2, 2020

Epigenetic drugs are an emerging class of cancer therapeutics. In this article, Ph.D. candidate Roshan Chikarmane introduces Foghorn Therapeutics, its co-founder, Cigall Kadoch, and the science behind their drug development program.

Roshan Chikarmane ⋅ Perspectives in Research Cancer, cancer treatment, drug development, epigenetics ⋅

Concept image of a structure of the genetic code.

Next Generation Cancer Diagnostics Revolutionize Patient Care

October 5, 2020

Next generation cancer diagnostics are poised to change the way that cancer is detected and treated. Ph.D. candidate Roshan Chikarmane shares his perspectives on the teams and technologies that are leading the charge.

Roshan Chikarmane ⋅ Perspectives in Research Cancer, cancer research, cancer treatment, diagnostics, Technology ⋅

Close up of a doctor doing a medical exam while both him and the patient are wearing protective masks.

Cancer in the Time of Coronavirus

September 16, 2020

Health care has pivoted in response to COVID-19, but how have these changes affected cancer patients? A student shares her perspective on having a parent with cancer during the pandemic.

Emily Marcisak ⋅ A Day in the Life Cancer, coronavirus, covid-19, pandemic ⋅

A pediatric patient is being comforted by her doctor while hooked up to an IV.

Chasing Cancer: How the COVID-19 Pandemic Affects Cancer Outcomes

July 27, 2020

Pulitzer Prize-winning author and oncologist Siddhartha Mukherjee along with former executive vice president of the American Cancer Society and Hopkins oncologist Otis Brawley spoke with the Washington Post about how COVID-19 affects cancer outcomes.

Palak Patel ⋅ Events and Happenings Cancer, coronavirus, covid-19, Oncology ⋅

A colorful illustration of the left and right sides of the brain.

The Longrifles Seminar: A Legacy of Collaboration

November 20, 2019

The Longrifles Cancer Seminar series, founded by Don Coffey, remains a hub of collaborative brainstorming for the Brady Urological Institute.

Carli Jones ⋅ Events and Happenings Brady Urological Institute, Cancer, collaboration, Seminar ⋅

A conceptual image of DNA strands in a test tube.

Cancer Diagnosis — It’s in Your Blood

September 23, 2019

The benefits of detecting and treating cancer at early developmental stages have long been observed by clinical oncologists. Colonoscopies as well as other methods for early detection have been estimated to prevent as many as 60% of deaths attributable to colorectal cancer by identifying and removing precancerous growths1. More broadly, patients with early stage cancer […]

Roshan Chikarmane ⋅ Perspectives in Research Cancer, cancerSEEK, diagnostics, early detection ⋅

A 3D render of DNA modification.

Cancer and the Mutation Paradox

May 10, 2019

It has long been known — thanks largely to work by Johns Hopkins’ own Bert Vogelstein — that cancer is a disease generally caused by an accumulation of genetic mutations. This is sometimes referred to as the somatic mutation theory.1 This hypothesis states that each time a cell divides and grows, there are opportunities for […]

Pavan Shah ⋅ Perspectives in Research Cancer, gene mutation, immunotherapy ⋅

Silver bullet in flight

Engineering Magic Bullets for Pancreatic Cancer

February 4, 2019

In a 1909 manuscript titled “Ueber den jetzigen Stand der Chemotherapie” (“About the Current State of Chemotherapy”), Nobel laureate Paul Ehrlich proclaimed, “We must learn to aim in a chemical sense.” What did he mean? Ehrlich was referring to his “magic bullet” theory of chemical specificity, the observation that certain drugs can eliminate disease-causing entities […]

Roshan Chikarmane ⋅ Perspectives in Research Cancer, cancer research, Pancreatic Cancer ⋅

Melanoma cells

The Colorful World of Cancer Drug Discovery

September 25, 2018

Melanoma cells stained with PTRF (in red), RPA194 (in green) and nucleus stained in blue. RPA194 is the main subunit of the RNA polymerase I (POL 1) enzyme. Our lab discovered a first-in-class small molecule that inhibits POL 1 enzyme and causes the destruction of RPA194 protein. Here, we are investigating how these proteins are […]

Jin-Yih Low ⋅ Perspectives in Research Cancer, cancer research, in the lab, Instagram ⋅

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