immunotherapy

Solving the CAR-T Conundrum

Solving the CAR-T Conundrum

Posted by  | Perspectives in Research

The development and commercialization of cancer immunotherapies, a class of treatments that fights cancer by fortifying the immune system, has advanced at a rapid pace. Prior to 2017, most cancer immunotherapies were composed of antibodies that selectively flag cancer cells for destruction by other cells in the immune system. In mid-2017, the FDA approved Kymriah(...)

More

The Link Between Metabolism and Anti-Tumor Immunity: Implications for Glioma Therapy

The Link Between Metabolism and Anti-Tumor Immunity: Implications for Glioma Therapy

Posted by  | Recently Published

As a callow biochemistry student, I often grappled with the onerous task of memorizing metabolic pathways. Gradually, however, I came to appreciate the underlying simplicity: Complex macromolecules are broken down to the same simple molecule. Metabolism is the workhorse of the cell — efficiently mining nutrients for energy, shunting surplus nutrients to build cellular structures,(...)

More

A Novel Cancer Immunotherapy Unveiled: Y-Traps

A Novel Cancer Immunotherapy Unveiled: Y-Traps

Posted by  | Recently Published

The human immune system is composed of a diverse array of cells, which collectively work to exterminate pathogenic entities in the body. Yet this system is able to recognize host, or self, tissues as “friendly” through a variety of so-called immune checkpoint signals. Many cancer types — including melanomas and breast cancers — exploit this(...)

More

Success Follows When Biomedical Engineering and Immunology Collaborate

Posted by  | Perspectives in Research

Kaitlyn Sadtler, a freshly minted Ph.D. from Johns Hopkins’ Cell and Molecular Medicine Graduate Program and Jennifer Elisseeff, Ph.D.,  recently had her thesis work published in Science, where she demonstrated the necessity of the adaptive immune system in fostering a pro-healing response following biomaterial implantation to provide scaffolding for cell growth and tissue repair. Extracellular(...)

More